Our pharmacist answer the latest question concerning whether or no your can take Benadryl (diphenhydramine) v Nyquil.

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At a glance

NyQuil consists of doxylamine, a sedating first-generation antihistamine. Benadryl consists of diphenhydramine, additionally a sedating first-generation antihistamine. Usage of both together rises the hazard of side impacts such together oversedation, dry mouth, dried eyes and also constipation.



In many cases, the is not recommended to take Benadryl (diphenhydramine) and also Nyquil together since they both save sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, i beg your pardon is an extremely closely related to diphenhydramine (the active ingredient in Benadryl). In fact, they room in the same class of medication, sedating first-generation antihistamines.

Taking two first-generation antihistamines with each other is considered "duplicate therapy" and increases the risk of side effects occurring.

What Is Benadryl?

Benadryl is classified as a very first generation antihistamine. The duration of action of the medicine is commonly 4-6 hrs per dose (25 mg to 50 mg).<2>

First generation antihistamines are well-known for your sedative effects and also CNS (central worried system) depressant effects. Many individuals can not tolerate the sedative effects of Benadryl (diphenhydramine) during the work and, therefore, only take it in ~ bedtime to combat insomnia.

What Is NyQuil?

Nyquil is a combination cold/cough product that includes the drug doxylamine, in addition to a pain/fever reducer (acetaminophen) and also a cough suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and is in the same class of medication together Benadryl (diphenhydramine).<3>

Interaction Explained

As proclaimed above, both doxylamine and also Benadryl (diphenhydramine) work the same means and space actually in the same course of medication.

They work-related by prevent the histamine-1 receptor in the body, which prevents histamine from binding come it and producing the symptom we space all very familiar with (e.g. Runny nose, watery eyes, etc...).

Since both drugs work-related the exact same way, utilizing both at the very same time is not recommended.

Combined use normally won"t provide any an ext benefit than taking one of two people alone. Additionally, taking them with each other not only boosts the risk of excessive sedation, it greatly increases the hazard of added adverse results such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high doses of sedating antihistamines have additionally been connected with excitation, agitation, and restlessness.<5>

When Is Use together Okay?

Having said that, there can be a case to take it the combination together.

Benadryl (diphenhydramine) has relatively strong proof for usage in stemming allergic reactions.

Studies present that Benadryl (diphenhydramine) can efficiently reduce itching and also swelling from reactions to things choose bee stings and also poison ivy.

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If girlfriend have currently taken a dose of Nyquil and are having an allergy reaction come something, taking a dose of Benadryl (diphenhydramine) may aid without a substantial increased risk in intolerable next effects.